MOTS-c 40mg | ≥98% Purity | UK Research Peptide
MOTS-c 40mg mitochondrial-derived research peptide, ≥98% purity, HPLC + MS verified. Lyophilised, UK batch-tested. In-vitro research only.
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- ✓ Independently HPLC + MS verified — per-batch Certificate of Analysis
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⚠ For laboratory research use only. Not for human or veterinary use. Must be 21+ to purchase.
MOTS-c 40mg is a synthetic 16-amino-acid mitochondrial-derived peptide supplied as lyophilised powder for laboratory research. Every batch is HPLC-verified to ≥98% purity with identity confirmed by mass spectrometry, and independently tested by an ISO 17025 accredited third-party laboratory. It is supplied strictly for in-vitro research use only.
MOTS-c 40mg at a Glance
| Product | MOTS-c 40mg |
| Quantity | 40mg per vial |
| Form | Lyophilised powder (requires reconstitution) |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | ≈2,174.6 Da |
| Purity | ≥98% (HPLC) |
| Identity | Confirmed by mass spectrometry |
| Testing | ISO 17025 accredited third-party laboratory, batch-specific certificate |
| Storage | Lyophilised: −20°C long term. Reconstituted: 2–8°C |
| Intended use | Research use only. Not for human or veterinary use. |
What Is MOTS-c?
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a peptide encoded within the mitochondrial genome rather than the nuclear genome. It was identified in 2015 as one of a small family of mitochondrial-derived peptides that act as signalling molecules between the mitochondria and the rest of the cell. Our MOTS-c 40mg vial contains the 16-residue sequence MRWQEMGYIFYPRKLR, with a molecular weight of approximately 2,174.6 Da.
Because it links mitochondrial state to nuclear gene expression and AMPK signalling, MOTS-c has become a widely used tool compound in metabolism and ageing research. The lyophilised format keeps the peptide stable in storage, and the peptide is also available as a 10mg vial for smaller study designs.
MOTS-c Research Areas
Laboratory studies of MOTS-c cover several areas of the published literature:
Metabolic Signalling
MOTS-c is studied for its activation of AMPK and its effects on glucose uptake, folate–methionine cycle metabolism and insulin signalling in cell and preclinical models. Published work can be explored on PubMed.
Mitochondrial–Nuclear Communication
Under metabolic stress MOTS-c translocates to the nucleus and regulates stress-responsive gene expression, making it a model peptide for retrograde signalling research.
Exercise Physiology Models
Preclinical studies examine how MOTS-c levels change with physical activity and how the peptide influences skeletal-muscle metabolism and endurance markers.
Ageing and Longevity Research
MOTS-c is investigated alongside other mitochondrial peptides in models of age-related metabolic decline. See our review of top compounds for cellular longevity research.
MOTS-c vs SS-31
Both are studied in mitochondrial research but work differently. MOTS-c is a signalling peptide that regulates gene expression and AMPK; SS-31 (Elamipretide) is a small tetrapeptide that binds cardiolipin in the inner mitochondrial membrane. Researchers often use the two in parallel to compare signalling-level and membrane-level interventions.
Why Researchers Choose MOTS-c 40mg from ThePeptideCode
- Verified purity: ≥98% by HPLC, with identity confirmed by mass spectrometry.
- Independent testing: every batch is tested by an ISO 17025 accredited third-party laboratory.
- Batch-specific certificates: the certificate matches the batch you receive.
- Accurate fill: 40mg of peptide per vial, lyophilised for stability.
- Fast UK dispatch: in-stock items are dispatched within one working day.
- UK Express delivery: £6.99, free on orders over £100.
Quality Control and Batch Testing
Every batch of MOTS-c 40mg is analysed before release. HPLC confirms purity, and mass spectrometry confirms that the peptide mass matches the expected sequence. You can view current certificates on our verification and testing page.
Storage and Handling
Store lyophilised MOTS-c at −20°C for long-term stability, protected from light and moisture. Reconstitute with bacteriostatic water using aseptic technique, then keep the solution refrigerated at 2–8°C and use promptly. See our guides on how to reconstitute peptides and how to store research peptides.
Research Use Only
MOTS-c 40mg is supplied strictly for in-vitro laboratory research. It is not a medicine, supplement or cosmetic product. It is not intended to diagnose, treat, cure or prevent any disease, and it is not for human or veterinary use. By purchasing, you confirm that the product will be used solely for lawful laboratory research.
MOTS-c 40mg FAQs
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene. It is studied as a signalling molecule linking mitochondrial state to metabolic gene expression and AMPK activity.
What is the molecular weight of MOTS-c?
Approximately 2,174.6 Da for the 16-residue sequence MRWQEMGYIFYPRKLR.
Does MOTS-c 40mg need reconstituting?
Yes. It is supplied as lyophilised powder and should be reconstituted with bacteriostatic water before use in research protocols.
How is MOTS-c 40mg tested?
Every batch is tested to ≥98% purity by HPLC, with identity confirmed by mass spectrometry, at an ISO 17025 accredited third-party laboratory.
How should MOTS-c be stored?
Keep the lyophilised vial at −20°C for long-term storage. Once reconstituted, refrigerate at 2–8°C and use promptly.
Is MOTS-c 40mg for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or veterinary use.