Melanotan II 10mg | ≥99% Purity | UK Research Peptide
Melanotan II (MT-II) 10mg cyclic α-MSH analogue research peptide, ≥99% purity, HPLC + MS verified. Lyophilised, UK batch-tested. In-vitro research only.
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- ✓ Independently HPLC + MS verified — per-batch Certificate of Analysis
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⚠ For laboratory research use only. Not for human or veterinary use. Must be 21+ to purchase.
Melanotan II 10mg (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone supplied as lyophilised powder for laboratory research. Every batch is HPLC-verified to ≥99% purity with identity confirmed by mass spectrometry, and independently tested by an ISO 17025 accredited third-party laboratory. It is supplied strictly for in-vitro research use only.
Melanotan II 10mg at a Glance
| Product | Melanotan II 10mg |
| Quantity | 10mg per vial |
| Form | Lyophilised powder (requires reconstitution) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Molecular formula | C50H69N15O9 |
| Molecular weight | ≈1,024.2 Da |
| CAS number | 121062-08-6 |
| Purity | ≥99% (HPLC) |
| Identity | Confirmed by mass spectrometry |
| Testing | ISO 17025 accredited third-party laboratory, batch-specific certificate |
| Storage | Lyophilised: −20°C long term. Reconstituted: 2–8°C, protected from light |
| Intended use | Research use only. Not for human or veterinary use. |
What Is Melanotan II?
Melanotan II is a cyclic analogue of α-MSH developed at the University of Arizona in the 1980s. A lactam bridge between the aspartate and lysine side chains locks the peptide into a rigid ring, and the D-phenylalanine substitution makes it far more resistant to enzymatic breakdown than the native hormone. The result is a potent, non-selective agonist at melanocortin receptors MC1R, MC3R, MC4R and MC5R. Our Melanotan II 10mg vial contains the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, with a molecular weight of approximately 1,024.2 Da.
Because it activates several melanocortin receptor subtypes, MT-II is a standard reference ligand in receptor pharmacology. The lyophilised format keeps the peptide stable in storage and lets researchers reconstitute to the concentration their protocol requires.
Melanotan II Research Areas
Laboratory studies of Melanotan II cover the following areas of the published literature:
Melanocortin Receptor Pharmacology
MT-II is used as a reference agonist in binding and cAMP assays on cells expressing MC1R, MC3R, MC4R and MC5R, and as the comparator for selective analogues. Published work can be explored on PubMed.
Melanocyte and Melanogenesis Models
Cultured melanocytes and skin-tissue models use MT-II to study MC1R-driven tyrosinase expression and pigment synthesis.
Central Melanocortin Signalling
Preclinical neuroscience research uses MT-II to probe MC3R and MC4R pathways in the hypothalamus and their role in energy-balance signalling.
Peptide Cyclisation Studies
MT-II is a classic case study in medicinal chemistry for how cyclisation and D-amino-acid substitution improve peptide stability and receptor affinity.
Melanotan II vs α-MSH and Melanotan I
Native α-MSH is a linear 13-residue peptide that is cleared within minutes in most systems. Melanotan I (afamelanotide) is a linear analogue with two substitutions and greater MC1R selectivity; Melanotan II is the cyclic, shorter analogue with broad receptor activity. Researchers choose MT-II when they want a stable, non-selective melanocortin agonist and Melanotan I when selectivity for MC1R matters.
Why Researchers Choose Melanotan II 10mg from ThePeptideCode
- Verified purity: ≥99% by HPLC, with identity confirmed by mass spectrometry.
- Independent testing: every batch is tested by an ISO 17025 accredited third-party laboratory.
- Batch-specific certificates: the certificate matches the batch you receive.
- Accurate fill: 10mg of peptide per vial, lyophilised for stability.
- Fast UK dispatch: in-stock items are dispatched within one working day.
- UK Express delivery: £6.99, free on orders over £100.
Quality Control and Batch Testing
Every batch of Melanotan II 10mg is analysed before release. HPLC confirms purity, and mass spectrometry confirms that the peptide mass matches the expected cyclic structure. You can view current certificates on our verification and testing page.
Storage and Handling
Store lyophilised Melanotan II at −20°C for long-term stability, protected from light and moisture. Reconstitute with bacteriostatic water using aseptic technique, then keep the solution refrigerated at 2–8°C, protected from light, and use promptly. See our guides on how to reconstitute peptides and how to store research peptides.
Research Use Only
Melanotan II 10mg is supplied strictly for in-vitro laboratory research. It is not a medicine, supplement or cosmetic product. It is not intended to diagnose, treat, cure or prevent any disease, and it is not for human or veterinary use. By purchasing, you confirm that the product will be used solely for lawful laboratory research.
Melanotan II 10mg FAQs
What is Melanotan II?
Melanotan II is a synthetic cyclic heptapeptide analogue of α-MSH that acts as a non-selective agonist at melanocortin receptors. It is used as a reference ligand in receptor and melanocyte research.
What is the molecular weight of Melanotan II?
Approximately 1,024.2 Da (molecular formula C50H69N15O9).
Does Melanotan II 10mg need reconstituting?
Yes. It is supplied as lyophilised powder and should be reconstituted with bacteriostatic water before use in research protocols.
How is Melanotan II 10mg tested?
Every batch is tested to ≥99% purity by HPLC, with identity confirmed by mass spectrometry, at an ISO 17025 accredited third-party laboratory.
How should Melanotan II be stored?
Keep the lyophilised vial at −20°C for long-term storage. Once reconstituted, refrigerate at 2–8°C, protect from light and use promptly.
Is Melanotan II 10mg for human use?
No. It is supplied strictly for in-vitro laboratory research and is not for human or veterinary use.